| Atlantic States Marine Fisheries Compact | 1949 |
| Audiology and Speech Language Pathology Interstate Compact | 2020 |
| Compact for Education | 1967 |
| Compact on Adoption and Medical Assistance | 1998 |
| Compact on Mental Health | 1959 |
| Counseling Compact | 2022 |
| Driver License Compact | 1993 |
| Emergency Management Assistance Compact | 1997 |
| Interstate Agreement on Detainers | 1965 |
| Interstate Agreement on Qualifications of Educational Personnel | 1969 |
| Interstate Compact for Adult Offender Supervision | 2002 |
| Interstate Compact for Juveniles | 1965 |
| Interstate Compact on Adoption and Medical Assistance | 1999 |
| Interstate Compact on Educational Opportunity for Military Children | 2009 |
| Interstate Compact on the Placement of Children | 1971 |
| Interstate Corrections Compact | 1979 |
| Interstate Environmental Compact | 1971 |
| Interstate Insurance Product Regulation Compact | 2005 |
| Interstate Library Compact | 1967 |
| Interstate Mining Compact | 1967 |
| Lake Wylie Marine Commission | 1987 |
| Multistate Lottery Agreement | 2006 |
| National Crime Prevention and Privacy Compact | 2003 |
| National Guard Mutual Assistance Compact | 1969 |
| Nonresident Violator Compact | 1980 |
| North Carolina-South Carolina Boundary Agreement | 2016 |
| North Carolina-Virginia Boundary Agreement of 1970 | 1970 |
| Nurse Licensure Compact | 2018 |
| Occupational Therapy Licensure Compact | 2022 |
| Physical Therapy Licensure Compact | 2017 |
| Psychology Interjurisdictional Compact | 2020 |
| Roanoke River Basin Bi-State Commission | 2002 |
| Southeastern Forest Fire Protection Compact | 1955 |
| Southern Dairy Compact | 1997 |
| Southern Growth Policies Compact | 1975 |
| Southern Regional Education Compact | 1948 |
| Southern States Energy Compact | 1965 |
| State Authorization Reciprocity Agreement | 2016 |
| Streamlined Sales Tax Agreement | 2005 |
| Uniform Unclaimed Property Act | 1999 |
| Virginia-North Carolina Boundary Agreement of 1791 | 1791 |
| Virginia-North Carolina Boundary Agreement of 1970 | 1970 |
| Virginia-North Carolina Interstate High-Speed Rail Compact | 2004 |
| Wildlife Violator Compact | 2008 |